Detailed view for EmuJ_000957600

Basic information

TDR Targets ID: 955696
Echinococcus multilocularis, ubiquitin conjugating enzyme e2 r1
Source Database / ID:  GeneDB

pI: 4.3058 | Length (AA): 291 | MW (Da): 32665 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00179   Ubiquitin-conjugating enzyme

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 185 3rz3 (A) 6 183 67.00 0.0000000021 1 1.45628 -1.63
9 174 4lad (A) 3 162 48.00 0 1 1.20445 -1.68
10 289 4ddg (A) 1 1138 22.00 0 1 1.1712 0.28
35 134 2fo3 (A) 30 117 36.00 0.000000000033 1 0.704943 -0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129084)

Species Accession Gene Product
Brugia malayi Bm1_12705   ubiquitin conjugating enzyme protein 3
Candida albicans CaO19_6529   hypothetical protein
Candida albicans CaO19.13882   ubiquitin-conjugating enzyme
Candida albicans CaO19.6529   ubiquitin-conjugating enzyme
Caenorhabditis elegans CELE_Y71G12B.15   Protein UBC-3
Dictyostelium discoideum DDB_G0284009   ubiquitin-conjugating enzyme E2
Dictyostelium discoideum DDB_G0288345   hypothetical protein
Drosophila melanogaster Dmel_CG7656   CG7656 gene product from transcript CG7656-RF
Echinococcus granulosus EgrG_000957600   ubiquitin conjugating enzyme e2 r1
Entamoeba histolytica EHI_100110   ubiquitin-conjugating enzyme family protein
Echinococcus multilocularis EmuJ_000957600   ubiquitin conjugating enzyme e2 r1
Homo sapiens ENSG00000099804   cell division cycle 34
Homo sapiens ENSG00000107341   ubiquitin-conjugating enzyme E2R 2
Leishmania braziliensis LbrM.32.1050   ubiquitin-conjugating enzyme protein, putative
Leishmania donovani LdBPK_321010.1   ubiquitin-conjugating enzyme protein, putative
Leishmania infantum LinJ.32.1010   ubiquitin-conjugating enzyme protein, putative
Leishmania major LmjF.32.0960   ubiquitin-conjugating enzyme protein, putative
Leishmania mexicana LmxM.31.0960   ubiquitin-conjugating enzyme protein, putative
Loa Loa (eye worm) LOAG_11770   ubiquitin conjugating enzyme protein 3
Mus musculus ENSMUSG00000020307   cell division cycle 34
Mus musculus ENSMUSG00000036241   ubiquitin-conjugating enzyme E2R 2
Saccharomyces cerevisiae YDR054C   SCF E2 ubiquitin-protein ligase catalytic subunit CDC34
Schistosoma japonicum Sjp_0015960   ko:K02207 ubiquitin-conjugating enzyme E2 R, putative
Schistosoma mansoni Smp_055960   ubiquitin-conjugating enzyme E2r
Schmidtea mediterranea mk4.006526.00  
Schmidtea mediterranea mk4.012783.00  
Trichomonas vaginalis TVAG_297260   ubiquitin-conjugating enzyme E2, putative

Essentiality

EmuJ_000957600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YDR054C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000957600 (Echinococcus multilocularis), ubiquitin conjugating enzyme e2 r1
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